Abstract
Hydroxytryptamine has been reported as an antagonist of in vivo neuromuscular paralysis in mice. Experiments to elucidate the mechanism of interaction between 5-hydroxytryptamine and cholinergic blocking agents were conducted. Cholinergic blocking agents tested were botulinum toxin, d-tubocurarine, nereistoxin and hemicholinium. 5-hydroxytryptamine was most effective in antagonizing in vivo cholinergic blockade about 1 hr after its injection. It was also found that 5-hydroxytryptamine lowered body temperature most effectively 1 hr after its injection. Agents other than 5-hydroxytryptamine, namely sodium pentabarbitone and formaldehyde, also lowered body temperature and antagonized in vivo neuromuscular paralysis. It is proposed that the prolonged survival of mice treated with 5-hydroxytryptamine and then challenged was a result of depressed body temperature with a concomitant slowing in the binding and/or activity of cholinergic blocking agents. In addition to hypothermia, edema was detected in rats and mice treated with 5-hydroxytryptamine. Further experiments are suggested to determine whether edema facilitates or antagonizes the hypothermic effect.
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