Abstract
L-asparaginase (L-ASP) is one of the key agents in the long-term chemotherapy of lymphoid malignancies in children with acute lymphoblastic leukemia (ALL) and non Hodgkin′s lymphoma (NHL). If L-ASP resistance occurs in patients, it is highly suggestive of poor prognosis.Therefore, the mechanism of L-ASP resistance is a major study in the field of diagnosis and treatment of leukemia in children.Over the years, related studies have shown that the base level of asparagine synthetase in tumor cells, bone marrow hematopoietic support cells, some adverse metabolic changes after L-ASP chemotherapy, and the L-ASP silencing inactivation induced by self neutralizing antibody can lead to L-ASP resistance.In this paper, according to the literature related reports in recent years, provide reference for domestic colleagues, in order to carry out the relevant basic and clinical research, to provide theoretical basis for the realization of individualization of chemotherapy. Key words: Leukemia; Chemotherapy; L-asparaginase; Drug resistance; Silent inactivation
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