Abstract
Neuronal calcium sensors represent a family of EF-hands proteins that regulate numerous neuronal processes in response to intracellular changes in Ca2+ concentration. Although members of this protein family share considerable sequence and structural similarities, they exhibit distinct metal binding properties as well as a wide range of interactions with diverse intracellular partners. Downstream Regulatory Element Antagonist Modulator (DREAM) is found among the NCS family, it is a multifunctional member which is involved in several processes such as memory and learning, pain sensitivity, kinetics of potassium channels and enzymatic activity of presenilin.
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