Abstract
Mechanical allodynia is a significant sensory abnormality in many patients with chronic neuropathic pain, either of peripheral or central origin. It is proposed that this condition results from central sensitization of ascending nociceptive tract cells receiving convergent input from mechanoreceptors and nociceptors. It is assumed that these cells signal pain and that they normally do not respond sufficiently to weak mechanical stimuli to exceed threshold for pain perception. However, strong nociceptive stimuli can sensitize these cells, increasing their responses to mechanical inputs to a level beyond pain threshold. Central lesions could have a similar effect by changing the bias of descending control systems.
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