Abstract
Measurements of the whole-body content of 241Am and its distribution in the body were made at 8, 10 and 12 yr following inhalation of the insoluble dioxide by a worker in 1965. Chelation therapy was administered at another center from 1967 to 1974 and excretion of over one-half the initial body burden of 2.1 microCi (77.7 kBq} was obtained. Since the cessation of therapy, a very slow decrease in body content was observed indicating a retention half-time of more than 100 yr. Longitudinal profile scans showed that the distribution of activity in the body remained essentially the same from 1973 to 1977. About one-fourth of the total body burden was in the chest region, and transverse profile scans of the chest showed that the majority of activity in that region was in the lungs; a slight decrease in the lung content was observed. The distribution of activity in the skeleton was extremely well correlated with the distribution of available bone surface area. An increase in the ratio of counts obtained from the liver region to those from the left side of the abdomen since the chelation therapy was halted indicated that there was redistribution of activity still taking place. The amount of activity translocated to the liver may justify the resumption of chelation therapy in the future.
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