Abstract
Transcatheter arterial chemo-embolization using Lipiodol® is one of the treatments for hepatocellular carcinoma. During this procedure, it is important to monitor the Lipiodol® deposited inside tumors. This study proposes a method for measurement of the temperature dependence of the velocity of sound in biological tissues. An ultrasonic pulse-echo method was used to measure the velocity of sound. The temperature coefficients of the velocity of sound for Lipiodol® was −2.82 m s−1 °C−1. Values of 1.07 and 1.59 m s−1 °C−1 were obtained for normal rat liver and cancerous liver tissue, respectively. Thus, this procedure may potentially allow for the evaluation of the infiltration of Lipiodol® inside tumors.
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