Abstract
To demonstrate the feasibility of measuring pulmonary hematocrit (Hct) in blood in vivo using oscillation of hyperpolarized 129Xe MR signals and its potential for disease assessment in animal models. Hyperpolarized 129Xe dynamic MR spectroscopy was performed on 10 anemia model rats and 10 control rats. A concise model based on hyperpolarized 129Xe MR signal oscillations was built for calculating pulmonary Hct. Blood tests and chemical shift saturation recovery were conducted on each rat to obtain Hct. Correlations of Hct obtained from different methods were analyzed using SPSS 22.0. Hct measurements were strongly correlated with blood test (Spearman correlation coefficient r = 0.871, p < 0.001) and chemical shift saturation recovery measurements (r = 0.956, p < 0.001). Hct was 0.198 ± 0.054 for the anemic cohort and 0.457 ± 0.039 for the control group (p < 0.001). We developed an approach that provided a way to quantify changes in pulmonary Hct using oscillations of hyperpolarized 129Xe signals. This method shows promise for noninvasive pulmonary Hct assessment and disease evaluation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callSimilar Papers
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
