Abstract
The biochemical investigation of carcinoid disease has relied on measurement of the daily excretion of 5-hydroxyindoleacetic acid (5HIAA) in urine. 1 Collection of 24-h urine has considerable disadvantages for the patient. Inconvenience, embarrassment, strict dietary requirements and the need for hazardous preservatives make this test unpopular, and signi® cant errors in collection may be made. The measurement of 5-HIAA in plasma would offer a more convenient alternative. However, the value of plasma 5-HIAA measurements in carcinoid disease has not been evaluated. Highperformance liquid chromatographic (HPLC) methods for measuring plasma 5-HIAA have been described previously, but applied to the investigation of patients with psychiatric and neurological disorders. 2 We describe a simple, isocratic HPLC method
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