Abstract
Although near infrared spectroscopy (NIRS) is primarily used to probe changes in oxyhaemoglobin (HbO2) and deoxyhaemoglobin (dHb) concentrations, it has long been realised that there is a significant oxygen-concentration dependent near infrared signal from the mitochondrial enzyme cytochrome c oxidase. In this paper we discuss the origins of this near infrared (NIR) signal, the possible factors affecting its intensity and its likely physiological and clinical significance. This paper complements our recent review on this subject1.
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