Abstract
Purpose. To measure the anterior chamber volume (ACV) and determine factors associated with the ACV in healthy Chinese adults. Methods. In this cross-sectional study, we used swept-source optical coherence tomography (SS-OCT) to measure ACV and other anterior segment parameters. Factors associated with ACV were also determined. Results. A total of 313 healthy Chinese adults were enrolled. The anterior segment parameters, including ACV, could be measured by SS-OCT with excellent repeatability and reproducibility. There was a significant difference between the horizontal and vertical anterior chamber widths (ACW) (P < 0.05), with a mean difference of 390 μm. The ACV (mean 153.83 ± 32.42 mm3) was correlated with most of the anterior segment parameters, especially anterior chamber depth (ACD), which accounted for about 85% of the variation of ACV. Most of the anterior segment parameters were significantly correlated with age, and the relative changes in ACV and ACD were greatest in subjects aged 41–50 years. Conclusion. ACV was correlated with most of the anterior segment parameters measured in this study, particularly ACD. The relatively large difference between horizontal and vertical ACW suggests that the ACV could and should be measured using multiple OCT scans.
Highlights
The anterior segment parameters, for example, the anterior chamber volume (ACV), are of significant interest to ophthalmologists [1, 2], especially glaucoma specialists
SD = standard deviation, axial lengths (AL) = axial length, IOP = intraocular pressure, ACV = anterior chamber volume, ACD = anterior chamber depth, anterior chamber widths (ACW)-H = anterior chamber width measured in the horizontal direction, ACW-V = anterior chamber width measured in the vertical direction, IV = iris volume, LV = lens vault, and PD = pupil diameter
CI = confidence interval, AL = axial length, IOP = intraocular pressure, PD = pupil diameter, LV = lens vault, IV = iris volume, ACW-H = anterior chamber width measured in the horizontal direction, ACW-V = anterior chamber width measured in the vertical direction, and ACD = anterior chamber depth
Summary
The anterior segment parameters, for example, the anterior chamber volume (ACV), are of significant interest to ophthalmologists [1, 2], especially glaucoma specialists. This is because ACV is closely associated with primary angle closure glaucoma (PACG), which is often characterized by a shallow and small anterior chamber [3,4,5]. An objective and reliable method of monitoring the anterior segment is of particular importance in the detection and follow-up of PACG. Optic coherence tomography (OCT) can be used for noncontact, objective measurements of the anterior segment [8], including the ACV [9]. Swept-source OCT (SS-OCT) systems can acquire a series of high-resolution OCT scans of the anterior segment within several seconds, and the ACV and other volumes of the anterior chamber can be calculated using four or more OCT scans [12]
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