Abstract
Systemic arterial and mixed venous plasma concentrations of 6-keto-PGF 1α and TxB 2 were measured by radioimmunoassay in 63 critically ill patients with major trauma (n = 20) or sepsis (n = 43). Patients undergoing elective catheterization procedures served as controls (n = 10). Arterial and mixed venous 6-keto-PGF 1α and TxB 2 levels were significantly elevated in patients with recent major trauma or active sepsis. The 6-keto-PGF 1α levels were found to be significantly elevated in the non-survivors and in patients with hepatic failure. The presence of severe pulmonary failure was not associated with increased levels of either 6-keto-PGF 1α or TxB 2. Comparison of arterial and mixed plasma samples did not demonstrate increased pulmonary release of either compound. Increased eicosanoid production may account, in part, for the local vascular and humoral responses to tissue injury or infection.
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