Abstract
In this study, the aim is to obtain new solubility data, correlation equation parameters of dipyrone and thermodynamic parameters in the dissolution process. The all would be useful for optimizing the crystallization process of dipyrone. The solubility of dipyrone was experimentally measured in mono solvents including methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, acetone, ethyl acetate, methyl acetate, water and binary mixtures (water+ethanol) at (293.15 to 332.85) K and atmospheric pressure by using a gravimetric method. The experimental solubility in the mono solvents was correlated by the Apelblat equation, van't Hoff equation, λh equation and nonrandom two-liquid (NRTL) equation. The solubility in the binary mixed solvents was correlated by the Apelblat equation, van't Hoff equation, λh equation, nonrandom two-liquid (NRTL) equation and Jouyban-Van't Hoff equation. The correlated values based on all the selected equations showed good agreement with the experimental values.
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