Abstract
Purpose The objective of this study was to evaluate central corneal thickness (CCT) in Chinese premature infants at different postnatal stages to study the peak point and analyze influential factors on CCT development. Methods This was a cross-sectional study of premature infants. Initial CCT measurement was taken at 34 weeks of gestational age (GA) and at intervals until 88 weeks of postmenstrual age (PMA) was reached. The comparison and correlation analysis were carried out to access the association of CCT with gender, birth weight (BW), GA, and retinopathy of prematurity (ROP) for each PMA. The premature infants were divided into the thick CCT group and the thin CCT group according to the average CCT at 40 w. And the difference in CCT between the two groups at subsequent 52 w and 64 w was compared. Results A total of 1726 premature infants (3463 measurements) with an average of 2.21 ± 1.57 measurements were included in this study. The CCT decreased from 34 w GA to 52 w PMA (R = 92.36, P < 0.0001) and then reached a plateau (R = 2.541, P=0.3567). Male (P < 0.05), low BW (P < 0.05), and low GA (P < 0.05) were associated with thicker CCT at the early stage of PMA. The premature infants who had thick CCT at 40 w would have thick CCT at 52 w and 64 w accordingly. Conclusions The CCT values of premature infants decreased over time and plateaued at 52 w PMA. Gender, BW, and GA were considered as the influential factors of CCT at the early stage of PMA. Moreover, CCT at 40 w could forecast its development trend at 52 w or 64 w after birth.
Highlights
Central corneal thickness (CCT) has become an important aspect of diagnosing and treating various eye disorders [1].ere are many techniques for measuring CCT, such as ultrasonic pachymetry, Visante optical coherence tomography, and Fourier-domain optical coherence tomography [2]. e accurate measurement of corneal thickness is vital to evaluate the endothelial function and to manage pediatric glaucoma [3]
Rebecca et al showed that CCT was a phenotypic risk factor for primary open angle glaucoma (POAG) in a genomic study [5]
Our study aimed to analyze the dynamic change in CCT in a large sample of premature infants within a period of 1 year and to explore whether gender, gestational age (GA), birth weight (BW), and presence of retinopathy of prematurity (ROP) could be influential factors in CCT changes
Summary
Central corneal thickness (CCT) has become an important aspect of diagnosing and treating various eye disorders [1]. Is agreed to the decrease in CCT with the growth of infants Overall, these studies had a shorter follow-up period and a relatively small sample size. Our study aimed to analyze the dynamic change in CCT in a large sample of premature infants within a period of 1 year and to explore whether gender, GA, BW, and presence of ROP could be influential factors in CCT changes. 2. Patients and Methods is study was a cross-sectional clinical trial conducted on premature infants at the Affiliated Eye Hospital of Wenzhou Medical University (Hangzhou, China), from February 2014 to April 2018. Patients and Methods is study was a cross-sectional clinical trial conducted on premature infants at the Affiliated Eye Hospital of Wenzhou Medical University (Hangzhou, China), from February 2014 to April 2018 It followed the tenets of the Declaration of Helsinki. A value of P < 0.05 was set for statistical significance
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