Abstract
BackgroundPediatric sleep-disordered breathing (SDB) correlated with respiratory conditions of snoring and hypopnea. Mean platelet volume (MPV) was an inflammatory marker, related to increased inflammatory condition of pediatric patients. Increase of MPV level may cause failure to thrive or increased upper airway infection rate. The aim of this study was to perform systematic review and meta-analysis to investigate the difference on MPV values for pediatric SDB, and compare the change on MPV after surgery in patients with pediatric SDB.MethodsA systemic review of the studies from PubMed, EMBASE, and Cochrane Library databases was conducted in March 2020, supported by reviewing of published articles for studies comparing MPV in pediatric SDB. Meta-analysis was used to compare the change of MPV in pediatric SDB, and sub-group analysis was also used to compare the MPV decrease after surgeries of adenoidectomy or adenotonsillectomy.ResultsThere were seven studies included in the review. Six of them including 963 subjects showed that a significant increase of MPV was noted in pediatric SDB compared to those in pediatric non-SDB (P < 0.05). Total standardized mean difference (SMD) in MPV between pediatric SDB and non-SDB was 0.51 (95% CI =0.30–0.72, P < 0.05). A significant decrease of MPV was found in pediatric SDB patients who underwent surgery (total SMD = − 0.36; 95% CI = − 0.70– -0.02, P < 0.05). Decreases of MPV after adenoidectomy and adenotonsillectomy were observed, but only the effect of adenotonsillectomy had a statistical significance (total SMD = − 0.72; 95% CI = − 1.18 – -0.26, P < 0.05).ConclusionThe MPV was significantly higher in patients with pediatric SDB, indicating the presence of increased platelet activity in pediatric SDB patients. The level of MPV could be reduced by the two surgeries, especially adenotonsillectomy.
Highlights
Pediatric sleep-disordered breathing (SDB) correlated with respiratory conditions of snoring and hypopnea
The pediatric SDB is correlated with pediatric upper respiratory tract infection, failure to thrive, pediatric hypertension [4, 5], and attention deficiency [2]
Our searching strategy was based on patient, indicator, control group and outcome (PICO): is there a difference on Mean platelet volume (MPV) values for pediatric SDB, and change on MPV after surgery in patients with pediatric SDB? The electronic databases of PubMed, EMBASE, and Cochrane Library were searched primarily based on the combination of the following keywords: “sleep-disordered breathing,” “adenotonsillar hypertrophy,” “Adenoid hypertrophy,” “mean platelet volume,” and “platelet” up to March 2020 and published in English
Summary
Pediatric sleep-disordered breathing (SDB) correlated with respiratory conditions of snoring and hypopnea. Pediatric sleep-disordered breathing (SDB) is characterized by loud snoring and or hypopnea at night and is associated with upper airway infections [1], attention disorder [2], and failure to thrive [3]. The pediatric SDB is correlated with pediatric upper respiratory tract infection, failure to thrive, pediatric hypertension [4, 5], and attention deficiency [2]. The association of pediatric SDB caused to increase interest in its role in upper respiratory tract infection [1], and pediatric hypertension [4, 5], failure to thrive (increased catabolic status by chronic inflammation) [3], and attention deficiency disorders [2]. Platelet volume correlated with cardiovascular disease [7], and coronary heart disease [8]
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