Abstract
The pathogenesis of hidradenitis suppurativa (HS) is yet to be fully understood. However, inflammation is a key element in the development of skin lesions. The aim of this study was to evaluate the expression of monocyte chemotactic protein-1-induced protein-1 (MCPIP1) in the skin of patients suffering from HS. Skin biopsies of 15 patients with HS and 15 healthy controls were obtained and processed for immunohistochemistry, western blot, and real time PCR. The highest mean MCPIP1 mRNA expression was found in the inflammatory lesional skin of HS patients. It was significantly higher than MCPIP1 mRNA expression in the biopsies from both healthy controls and non-lesional skin of HS patients. Western blot analysis indicated that expression of MCPIP1 was elevated within both lesional and non-lesional skin compared to the healthy control. The increased MCPIP1 mRNA and protein expression level in HS lesions may indicate its possible role in the disease pathogenesis.
Highlights
The highest mean monocyte chemotactic protein-1-induced protein-1 (MCPIP1) mRNA expression was found in the inflammatory lesional skin of hidradenitis suppurativa (HS) patients (HS-1: lesional skin) (0.0236 ± 0.0134)
It was significantly higher than MCPIP1 mRNA expression in the biopsies from both healthy controls (CTR) (0.0080 ± 0.0034, p < 0.001) and non-lesional skin of HS patients (HS-2: non-lesional skin) (0.0049 ± 0.0034, p < 0.001) (Figure 1A)
Western blot analysis indicated that expression of MCPIP1 was elevated within both lesional (2,5-fold increase) and non-lesional skin (2,3-fold increase) compared to the healthy control (Figure 1B,C)
Summary
Usually beneficial and life-preserving, disturbances of the innate immune system may lead to development of immune-mediated diseases [3]
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