Abstract
Matrix-producing carcinoma (MPC) is a rare subtype of metaplastic breast carcinoma (MBC) that was first described in 1989 by Wargotz and Norris. It accounts for less than 1% of breast carcinomas and has distinctive clinical, morphological, and immunohistochemical features. Histologically it consists of invasive carcinoma of no special type with transition to cartilaginous or osseous matrix without a spindle cell component. Data on this entity are limited with the literature consisting mostly of case reports and a small number of case series.We report a case of matrix-producing breast carcinoma, with excellent clinical outcome. We also discuss the histogenesis, imaging, histological, and immunohistochemical characteristics, treatment, and focus on the differential diagnosis of this rare tumor.
Highlights
Metaplastic breast carcinoma (MBC) is a heterogeneous group of malignant epithelial tumors that undergoes metaplasia into mesenchymal or squamous differentiation
Matrix-producing carcinoma (MPC) is a rare subtype of metaplastic breast carcinoma (MBC) that was first described in 1989 by Wargotz and Norris. It accounts for less than 1% of breast carcinomas and has distinctive clinical, morphological, and immunohistochemical features. It consists of invasive carcinoma of no special type with transition to cartilaginous or osseous matrix without a spindle cell component
We report a case of matrix-producing breast carcinoma, with excellent clinical outcome
Summary
Metaplastic breast carcinoma (MBC) is a heterogeneous group of malignant epithelial tumors that undergoes metaplasia into mesenchymal or squamous differentiation. This group currently includes fibromatosis-like metaplastic carcinoma, low-grade adenosquamous carcinoma, spindle cell carcinoma, carcinoma with mesenchymal differentiation, and squamous cell carcinoma. They are very rare accounting for less than 1% of breast carcinomas. Matrix-producing carcinoma (MPC) is a rare subtype of MBC. It is defined as a carcinoma with a direct transition from invasive carcinoma no special type to cartilage or osseous component lacking an intervening spindle cell component [1]. The patient received adjuvant chemotherapy and is alive without evidence of recurrence or distant metastasis 38 months after surgery
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
