Abstract
We aimed to systematically investigate the potential association of matrix metalloproteinase (MMP)-9, -3, -2, and -8 gene polymorphisms with susceptibility to periodontitis using meta-analysis. A literature search in PubMed, Embase, and Web of Sciencewas conducted to obtain relevant publications. Finally a total of 16 articles with 24 case-control studies (nine on MMP-9-1562 C/T, seven on MMP-3-1171 A5/A6, four on MMP-2-753C/T, and four on MMP-8-799 C/T) were considered in this meta-analysis. The results based on 2,724 periodontitis patients and 3,438 controls showed that MMP-9-1562C/T, MMP-3-1171 A5/A6, and MMP-8-799C/T polymorphisms were associated with periodontitis susceptibility. No significant association was found between MMP-2-753 C/T and periodontitis susceptibility. Subgroup analyses suggested that the MMP-9-1562 C/T polymorphism reduced chronic periodontitis susceptibility and MMP-3-1171 A5/A6polymorphism increased chronic periodontitis susceptibility. In summary, current evidence demonstrated that MMP-9-753 C/Tpolymorphism reduced the risk of periodontitis, MMP-3-1171 5A/6A and MMP-8-799 C/Tpolymorphisms increased the risk of periodontitis, and MMP-2-753 C/T was not associated with risk of periodontitis.
Highlights
We aimed to systematically investigate the potential association of matrix metalloproteinase (MMP)-9, -3, -2, and -8 gene polymorphisms with susceptibility to periodontitis using meta-analysis
Our results provided some evidence to support an elevated risk between periodontitis susceptibility and MMP-3-1171 A5 allele and MMP-8-799 T allele, and a reduced risk between periodontitis susceptibility and MMP-9-1562 T allele
Our study provided no evidence to support an association between MMP-2-753 C/T polymorphism and periodontitis
Summary
We aimed to systematically investigate the potential association of matrix metalloproteinase (MMP)-9, -3, -2, and -8 gene polymorphisms with susceptibility to periodontitis using meta-analysis. In addition to bacterial infection, individuals’ susceptibility to periodontitis is likely to be of major importance in determining the manifestation and progression of the disease[10]. Genetic factors, such as cyclooxygenase-2 gene polymorphisms and interleukin gene polymorphisms had been demonstrated by meta-analyses that whether they were associated with periodontitis susceptibility[11,12,13,14,15,16]. The results still remain inconsistency and individual studies based on small sample sizes have low statistical power to investigate the real association[22] These facts warranted us to perform a meta-analysis to further investigate the role of these polymorphisms in the pathogenesis of periodontitis
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