Abstract
An approach to estimation of the immune system efficiency is proposed in the paper. The sum of energy costs of the immune system support and the body losses caused by infectious diseases determines the energy value of the immune system protection. It is assumed that the state of the immune system providing the minimum energetic cost for the given environment is the norm, because it increases adaptability. The adaptation of the immunity to external conditions is realized through the minimization of the energy cost. The adaptation of the immune system may result in the maintenance of chronic infections and formation of immunodeficiency. Mathematical models of an immune system should be constructed as components of a model of the homeostatic maintenance supersystem.
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