Abstract
The model of an isolated organ system has been constructed to simulate the behavior of drug in the circulatory system of an acting organ or site. The model is developed on the following assumptions: The drug in the microcirculatory system cannot permeate the capillary walls. The capillary bed is modeled as a simple ideal plug flow system with and without radial concentration gradient. The mathematical model is developed from basic considerations of drug distribution with hemodynamical and pharmacokinetical meanings.
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