Abstract
Objective: This study was designed to discriminate between fetal growth restriction that is placentally mediated and constitutionally small fetuses depending on the measurement of placental growth factor (PlGF) in the maternal circulation. Study Design: This was a prospective case–control study. Settings: This study was conducted at the Department of Gynecology and Obstetrics at Al-Yarmouk Teaching Hospital. Patients and Methods: The study included 100 cases (11 placental intrauterine growth restriction [IUGR] and 89 constitutionally small) with singleton pregnancies. Serum PlGF was measured by ELISA technique. Concentration less than the 5th percentile for normal pregnancy was considered a positive PlGF test. Results: A positive PlGF test was found in 10 out of the 11 placental growth restriction cases and in 4 out of the 89 constitutionally small fetuses. PlGF can differentiate between IUGR due to placental dysfunction from constitutionally small fetuses with 90.1% sensitivity and 95.5% specificity. Conclusion: PlGF may serve as a promising tool to identify placental IUGR antenatally.
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