Maternal obesity during pregnancy as a risk for early-life asthma

Gestational weight gain and offspring asthma: a novel opportunity for primary prevention research.

Influence and Mechanisms of Maternal and Infant Diets on the Development of Childhood Asthma

Environmental factors

The placenta is the center of the chronic disease universe

Higher BMI is associated with worse asthma control and quality of life but not asthma severity

Viral respiratory tract infections and asthma: The course ahead

Influence of heredity on asthma continues to adulthood

BackgroundA causal relationship between maternal obesity and offspring asthma is hypothesized to begin during early development, but no underlying mechanism for the found association is identified. We quantitatively examined mediation by offspring body mass index (BMI) in the association of maternal pre-pregnancy BMI on risk of asthma and wheezing during the first 7–8 years of life in a large Amsterdam born birth cohort.MethodsFor 3185 mother-child pairs, mothers reported maternal pre-pregnancy BMI and offspring outcomes “ever being diagnosed with asthma” and “wheezing in the past 12 months” on questionnaires. We measured offspring height and weight at age 5–6 years. We performed a multivariate log linear regression comparing outcomes in offspring of mothers with different BMI categories. For each category we quantified and tested mediation by offspring BMI and also investigated interaction by parental asthma.ResultsAt the age of 7–8 years, 8% of the offspring ever had asthma and 7% had current wheezing. Maternal pre-pregnancy obesity was associated with higher risks of asthma (adjusted RR 2.32 (95% CI: 1.49–3.61) and wheezing (adjusted RR 2.16 (95% CI: 1.28–3.64). Offspring BMI was a mediator in the association between maternal BMI and offspring wheezing, but not for asthma. There was no interaction by parental asthma.ConclusionsMaternal pre-pregnancy obesity was associated with higher risks of offspring asthma and wheezing. The association between maternal obesity and offspring wheezing was both direct and indirect (mediated) through the child’s own BMI.

Female overweight is not associated with a higher embryo euploidy rate in first trimester miscarriages karyotyped by hysteroembryoscopy

Roles of pollution in the prevalence and exacerbations of allergic diseases in Asia

Challenges in defining and classifying the preterm birth syndrome

What Is the Best Way To Measure Lung Function?

Maternal obesity, gestational weight gain, and offspring asthma and atopy

Preconception Women’s Health and Pediatrics: An Opportunity to Address Infant Mortality and Family Health

Risk of asthma