Abstract
Maternal neutralizing antibodies against a CRF01_AE primary isolate are associated with a low rate of intrapartum HIV-1 transmission in Thailand
Highlights
Mother-to-child transmission (MTCT) of HIV-1 provides a model for studying the role of passively acquired antibodies in preventing infection
We investigated the molecular characteristics of the MBA envelope glycoprotein (Env) that might explain this association
We measured and compared the titers of neutralizing heterologous antibodies (NAbs) against six primary isolates (3 CRF01_AE and 3 clade B strains) in sera from 45 transmitting (T) and 45 nontransmitting (NT) Thai mothers matched for baseline viral load and duration of zidovudine prophylaxis, the two main independent factors associated with MTCT
Summary
Maternal neutralizing antibodies against a CRF01_AE primary isolate are associated with a low rate of intrapartum HIV-1 transmission in Thailand. Giang-Huong, Alain Moreau, Pranee Leechanachai, Marc Lallemand, Françis Barin and Martine Braibant. Address: 1Université François Rabelais, Tours, France, 2Chiang Mai University, Chiang Mai, Thailand, 3Harvard School of Public Health, Boston, USA and 4Institut de Recherche pour le Développement, Chiang Mai, Thailand. Published: 22 July 2009 Retrovirology 2009, 6(Suppl 1):P5 doi:10.1186/1742-4690-6-S1-P5. Fifth Dominique Dormont International Conference. Host-Pathogen Interactions in Chronic Infections Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1742-4690-6-S1-info.pdf
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