Abstract
Sulfonamides are widely used to treat infectious diseases during pregnancy. However, the safety of maternal exposure to sulfonamides is controversial. This study aims to systematically review the available studies and examine the effect of maternal sulfonamides use on adverse pregnancy outcomes. We searched PubMed, Science Direct, Web of Science, ClinicalTrials.gov, CNKI and Wanfang Database (in Chinese). The meta-analysis used random effects model or fixed effects model to obtain the total odds ratio (OR) for each outcome through Stata11.0 software. Study on the relationship between sulfonamide exposure during pregnancy and adverse pregnancy outcomes. The study design covered randomized controlled trials, cohort studies and case-control studies. The study protocol was registered in PROSPERO with protocol number CRD42020178687. A total of 10 studies, and 1096350 participants were included for systematic review. Maternal exposure to sulfonamides was found to be possibly associated with increased risk of congenital malformations (OR = 1.21, 95% CI 1.07-1.37). The use of sulfonamides in the first trimester of pregnancy and during the entire pregnancy might be associated with congenital malformations. Maternal exposure to sulfonamides may be associated with offspring' s congenital malformations. Prescription of sulfonamides for pregnant women is suggested to be carefully censored.
Highlights
Sulfonamides are a very important class of drugs, with antibacterial, diuretic, hypoglycemic, antithyroid activity and other pharmacological effects [1]
Maternal exposure to sulfonamides was found to be possibly associated with increased risk of congenital malformations (OR = 1.21, 95% confidence interval (CI) 1.07–1.37)
The results showed that maternal exposure to sulfonamides was associated with a high risk of congenital malformations (OR = 1.21, 95% CI 1.07–1.37)
Summary
Sulfonamides are a very important class of drugs, with antibacterial, diuretic, hypoglycemic, antithyroid activity and other pharmacological effects [1]. They are usually used as human medicines, agriculture, aquaculture and animal husbandry [2]. Sulfonamides are the first drugs to be systematically used to prevent and treat human bacterial infections [4]. Because infections during pregnancy often cause serious maternal and fetal complications, sulfonamides have been used as first-line agents in the second and third trimesters to treat and prevent urinary tract infections and other infections caused by susceptible microorganisms. This study aims to systematically review the available studies and examine the effect of maternal sulfonamides use on adverse pregnancy outcomes
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