Abstract
Pregnant rats (n=45) were fed alcohol (29% of kcal) in a high protein (31% of kcal) liquid diet on days 6 through 19 of gestation. On day 1 (day 0 is day of birth), litters were culled to 8 pups, 4 males and 4 females when possible. Samples for blood assays, organ weights and thymus samples for histologic preparation were obtained from pups culled from the litters. Pups were randomly selected for urinary pH testing, blood assays, thymus studies and liver lipid assays on days 1, 16, 21 and 30 and for sciatic nerve myelin assay on day 21. Hematology, thymus protein and structure, liver lipids and cholesterol, and sciatic nerve myelin were unharmed by in utero alcohol exposure in the presence of a high protein diet. At day 16, body and brain weights of alcohol exposed pups were decreased and urinary pH levels were higher than those of pairfed and ad libitum controls. In utero alcohol exposure (29%) in a diet containing 31% kcal as protein did not affect hematology, liver and thymus structure or peripheral nerve myelin; but did have early affects on body, brain, kidney and thymus weights and urinary pH levels.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
