Abstract
Neonatal hypoglycemia is frequently observed following pregnancies complicated by diabetes. This might be a result of decreased glycogenolysis/gluconeogenesis caused by neonatal hyperinsulinemia. The aim of the study was to investigate the capacity for production of glucose and glycerol, a glucose precursor, in infants of diabetic and healthy mothers. Subjects and methods: Eight normoglycaemic, fasting, term infants from diabetes pregnancies (IDDM/GDM) and two control infants were studied at a postnatal age of 4-10 h. The glucose (GPR) and glycerol production rates (GlycPR) were studied by use of 6,62H2-glucose and 2-13C-glycerol. The isotopic enrichments and concentrations of glucose (P-gluc) and glycerol (P-glyc) in plasma were analyzed Isotopic enrichments were measured by gas chromatography/mass spectrometry during periods of steady slate and were used for calculation of production rates. Conclusion: Normoglycaemic infants of diabetic mothers have capacity for glucose and glycerol production, at rates similar to those in control infants.
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