Abstract
BackgroundThe mechanical characterization of infant porcine cerebellum tissue in tension at high strain rate is crucial for modeling traumatic cerebellum injury, which is in turn helpful for understanding the biomechanics of such injuries suffered in traffic accidents.Material and MethodIn this study, the infant porcine cerebellum tissue was given three loading velocities, ie, 2s-1, 20s-1 and 100s-1 with up to 30% strain to investigate the tensile properties. At least six tensile tests for each strain rate were validly performed. Fung, Gent, Ogden and exponential models were applied to fit the constitutive equations, so as to obtain material parameters from the experimental data.ResultsThe Lagrange stress of infant porcine cerebellum tissue in tension appeared to be no more than 3000Pa at each loading velocity. More specifically, the Lagrange stress at 30% strain was (393.7±84.4)Pa, (928.3±56.3)Pa and (2582.4±282.2)Pa at strain rates of 2s-1, 20s-1 and 100s-1, respectively. Fung (0.833≤R2≤0.924), Gent (0.797≤R2≤0.875), Ogden (0.859≤R2≤0.944) and exponential (0.930≤R2≤0.972) models provided excellent fitting to experimental data up to 30% strain.ConclusionsThe infant cerebellum tissue shows a stiffer response with increase of the loading speed, indicating a strong strain-rate sensitivity. This study will enrich the knowledge on the material properties of infant brain tissue, which may augment the biofidelity of finite element model of human pediatric cerebellum.
Highlights
The infant cerebellum tissue shows a stiffer response with increase of the loading speed, indicating a strong strain-rate sensitivity
This study will enrich the knowledge on the material properties of infant brain tissue, which may augment the biofidelity of finite element model of human pediatric cerebellum
High quality experimental data on the mechanical characterization of infant human cerebellum tissue is essential for enhancing the bio-fidelity of computational pediatric cerebellum models, such as finite element pediatric cerebellum models, which can accurately simulate the brain’s response to complex loading conditions
Summary
High quality experimental data on the mechanical characterization of infant human cerebellum tissue is essential for enhancing the bio-fidelity of computational pediatric cerebellum models, such as finite element pediatric cerebellum models, which can accurately simulate the brain’s response to complex loading conditions. The properties of cerebrum tissue in tension are less well characterized than those in other loading modes, with only a few studies reporting tensile properties [9, 10, 11]. It is generally understood that cerebrum tissue is sensitive to strain rate, even at very high loading rates of 1000–3000 s-1 [1]. The mechanical characterization of infant porcine cerebellum tissue in tension at high strain rate is crucial for modeling traumatic cerebellum injury, which is in turn helpful for understanding the biomechanics of such injuries suffered in traffic accidents.
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