Abstract
We report first successful allogenic hematopoetic stem cell transplant of adult male with leukocyte adhesion deficiency. This patient was symptomatic for recurrent pyoderma gangrenosum since 10 years. He had received local treatments, systemic antibiotics, steroids, and cyclosporin but pyoderma was refractory leading to delay in hematopoetic stem cell transplant. The graft source was peripheral blood from 6/6 matched sibling. The conditioning regimen used was Busulphan, Cyclophosphamide, and antithymocyte globulin. Neutrophil engraftment occurred on day +14 and platelet engraftment occurred on day +24. Chimerism study of day +30 with VNTR showed 100% donor chimerism with normalization of CD18 expression.
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