Abstract
Objective: To make a comparative analysis of the parameters of bone remodeling lipid, calcium – phosphor exchange and 25-hydroxycholecalciferol (25(OH)D) level in elderly women with uncomplicated arterial hypertension (AH) and without it Design and method: The study included 44 patients with AH stage I-II (mean age - 69.1 ± 0.7 years, average duration of postmenopausal period - 18.4 ± 0.9 years) and 30 practically healthy women (mean age - 69.3 ± 1.2 years, average duration of postmenopausal period - 19.4 ± 1.2 years). All patients underwent general clinical and laboratory examination with determination of lipid level in blood, level 25(OH)D, parathyroid hormone, propeptide procollagen of type 1 aminoterminal (P1NP), β-isomerized C-terminal telopeptides (β-CTx), ionized calcium and phosphorus in serum, daily monitoring of blood pressure (BP), echocardiography and applanation tonometry. Results: In patients of the main group, compared with the control group, hypercholesteremia was revealed (total cholesterol (TCh) level of 6.3 ± 0.18 and 4.6 ± 0.1 mmol/L, low density lipoproteins (LDL) 3.8 ± 0.2 mmol / L and 2,1 ± 1,2, triglycerides (TG) 1,8 ± 0,1 and 1,0 ± 0,1 mmol / l, respectively, all p < 0,001), insufficiency and deficiency 25(OH)D (23, 76 ± 1.1 ng / ml and 28.18 ± 2.1 ng / ml, p < 0.05), secondary hyperparathyroidism (parathyroid hormone (PTH) - 64.6 ± 3.9 ng / ml and 39.56 ± 1.1 ng / ml, p < 0.001), accelerated resorption of bone tissue (β-CTx 0.57 ± 0.03 and 0.45 ± 0.03 ng / ml, p < 0.01). A direct propotional correlation between the level of TCh, LDL and P1NP (r = +0.417; r = +0.481, all p < 0.01) indicates a link between hypercholesterolemia and bone remodeling activity in elderly patients with uncomplicated hypertension.. Conclusions: In elderly women with controlled uncomplicated hypertension compared with healhy ones of corresponding age, lesion of mineralization of bone tissue is associated with decrease in the level of 25(OH) D, hypercholesterolemia, secondary hyperparathyroidism
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