Abstract
Background: Several treatment options are available for restorative dental treatment of moderate to large teeth defects. However, in recent years, improved computer-aided design and computer-aided manufacturing (CAD/CAM) technology show several advantages, including favorable esthetic results, conservative preparation techniques and cost-effectiveness hence the aim of the study was to search for the best available evidence in investigating whether CAD/CAM fabricated partial coverage restorations will show better marginal adaptation and provide an evidence-based clinically relevant statement.
 Methodology: An extensive search was performed using four online databases. Search strategies were developed for each online database, the studies were reviewed by three independent authors, and inclusion/exclusion criteria were applied and the quality of the included studies was assessed. Results: The initial search resulted in 998 studies from all the databases. Six clinical studies were identified as relevant to the research question and were included in the qualitative assessment.
 Conclusions: Marginal adaptation of CAD/CAM-fabricated restoration shows excellent clinical outcomes in short-term observation periods. There is a need for clinical trials that compare the clinical outcomes of CAD/CAM-fabricated restoration to direct composite restorations.
Highlights
Increasing demand for conservative dental treatments has raised the mandate for improving the manufacturing process of ceramic restorations [1]
There is a need for clinical trials that compare the clinical outcomes of computer-aided design and computeraided manufacturing (CAD/CAM)-fabricated restoration to direct composite restorations
CAD/CAM restoration offers ease of use and speed; as traditional impressions take longer compared to scanning, and the milling machine is on site, which means patients can have the restoration performed on the same day, CAD/CAM can potentially offer reduced cost of treatment [6]
Summary
Increasing demand for conservative dental treatments has raised the mandate for improving the manufacturing process of ceramic restorations [1]. Despite the frequent use of traditional impression techniques for fabrication of dental restoration, computer-aided design and computer-aided manufacturing (CAD/CAM) provide enhanced alternatives due to the speed of the process of fabrication [4]. CAD/CAM restoration offers ease of use and speed; as traditional impressions take longer compared to scanning, and the milling machine is on site, which means patients can have the restoration performed on the same day, CAD/CAM can potentially offer reduced cost of treatment [6]. In recent years, improved computer-aided design and computeraided manufacturing (CAD/CAM) technology show several advantages, including favorable esthetic results, conservative preparation techniques and cost-effectiveness the aim of the study was to search for the best available evidence in investigating whether CAD/CAM fabricated partial coverage restorations will show better marginal adaptation and provide an evidence-based clinically relevant statement. Six clinical studies were identified as relevant to the research question and were included in the qualitative assessment
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