Abstract
Publisher Summary Marek's disease (MD)—a malignant lymphomatosis in chickens—is caused by Marek's disease virus (MDV) of the family Herpesviridae. This chapter reviews recent advances in MD research, especially in the field of molecular biology. Various antigens present in MDV virions, MDV-infected cells, or MD lymphoma cells have been suspected as targets of vaccinal immunity and some of them have been identified by molecular biology techniques, especially with monoclonal antibodies. Of these antigens, the target antigens to vaccinal immunity in vaccinated chickens are expected to be present on the surface of MDV virions, MDV-infected cells, and MD lymphoma cells. In addition, the virus-specific cell surface antigen (CSA) as a target of vaccinal immunity is expected to be immunologically common to vaccine viruses and oncogenic MDV. The chapter also discusses the CSAs of vaccinal immunity.
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