Abstract
“ . . . are fetal transplantation approaches really leading to something better?” Hauser et al. report results of a seven-patient open-label study of bilateral transplantation of human fetal striatal cells in Huntington’s disease (HD). In a subject who died 18 months after transplantation, autopsy demonstrated surviving grafts of typical developing striatal morphology. Three subjects developed subdural hemorrhages and two required surgical drainage. see page 687 “If we replace only 8 to 10% of the striatum, which represents only 20% of the degeneration in HD, are we likely to have a major impact?” The accompanying editorial by Greenamyre and Shoulson emphasizes the compelling need for treatment for desperate patients with HD. However, striatal degeneration, while characteristic of HD, in only part of the disease and is often the least disabling. While it is logical …
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