Abstract
bilaterally in the insular cortices, and in the superior frontal gyrus and left caudate relative to the healthy group. No significant differences were detected between the first-episode and either the chronic psychosis or healthy control groups. Grey matter deficits did not appear to be related to the severity of positive, negative, general or total illness symptoms, the age of illness onset or medication exposure. Discussion: Grey matter deficits observed later in illness course may not be present to the same extent at the time of first episode of psychosis. However, this would warrant further investigation using small volume correction applied to examine regions strongly implicated in the pathophysiology of schizophrenia including frontal cortical regions. Our findings are in line with those of the previous literature in identifying reduced grey matter in schizophrenia in frontal and temporal cortical regions.
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