Mapping of the Neural Circuits that Control Intrinsic Lung Function

Abstract

The lung is commonly known as the gas‐exchange organ. However, given its vast surface area and direct exposure to the atmospheric environment, it is also an under‐recognized major sensory organ. The lung is exposed to signals such as oxygen, carbon dioxide, allergens, pollutants, pathogens, and subjected to mechanical stretch. Little is known on how these stimuli are sensed, processed and translated into distinct physiological outputs, including immune cell infiltration, airway tone and pulmonary blood pressure, all responses at the core of lung diseases. The lung is richly innervated. Multiple lines of evidence support that neural innervation controls many aspects of lung function. In this NIH SPARC funded research, we have used an array of cutting‐edge technologies to map the pattern determine the specific role of the neurons in modulating lung responses to inputs. Knowledge on the anatomical architecture as well as molecular code of the lung innervating neurons will set the foundation for modulating these circuits with precision.Support or Funding InformationNIH 1OT2OD023857‐01S3