Abstract
Severe hepatitis is induced with D-galactosamine hydrochloride in rats. Animals develop brain edema which was treated with mannitol. 1 h after the last mannitol infusion brain water content decreased, but it was not decreased 6 h after treatment. The therapy reduced lethality (p<0.025). The rigorous brain edema therapy impoved the prognosis of fulminant hepatic failure in the rat.
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