Abstract
PERSPECTIVE is a large-scale, international research project that aims to develop a risk stratification approach for breast cancer screening. This project involving many researchers as well as samples and data from 30 different countries creates novel ethical challenges. We discuss some specific issues that have arisen in the context of the PERSPECTIVE project as well as the innovative strategies conceived to address them. Even in the absence of an overarching international organization for the ethics review of multisite research projects, an adapted, flexible ethical framework, together with customized sample and data sharing tools, and a multi-step process for ethics approvals were successful strategies.
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