Abstract
s 271 LDL-C: 83 mg/dL). Relative to baseline and compared with placebo, IPE 4 g/day was found to significantly reduce median TG (primary endpoint), and to reduce LDL-C and apolipoprotein B (ApoB) (secondary endpoints). Purpose: To determine the effects of IPE in the ANCHOR study on: the exploratory endpoints of lipoprotein particle concentration; the correlation with ApoB; and the fatty acid desaturation index (FADI), a biomarker of hepatic stearoylCoA desaturase (SCD) activity (the key enzyme involved in the synthesis of monounsaturated fatty acids from saturated fatty acids). FADI can assess SCD activity, which has clinical relevance to TG levels, cardiovascular disease, metabolic disease, and certain cancers. Methods: ANCHOR(N5 702)was a phase 3,multicenter, placebo-controlled, randomized, double-blind, 12-week study. Lipoprotein particle concentration was measured by nuclear magnetic resonance spectroscopy. The FADI (eg, the ratios of palmitoleic acid to palmitic acid [C16:1/C16:0] and oleic acid to stearic acid [C18:1/C18:0]) was examined in plasma and red blood cells (RBCs). Results: Relative to baseline and compared with placebo, IPE4g/day significantly reducedmedianconcentrationsof total very-low-density lipoprotein (VLDL; 12.2%, P, 0.001), total LDL (7.7%,P,0.01), total high-density lipoprotein (7.4%,P, 0.0001), and small LDL particles (13.5%, P , 0.0001). Atherogenic lipoprotein particle (total VLDL and total LDL) OM3-FFA 2 grams/day (N537) OM3Diabetes BL %Change LS Mean %Change Median BL TG 749 -29 -26 639 Non-HDL-C 195 -12 -11 211
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