Abstract
BackgroundTo investigate the clinical and pathological characteristics of appendiceal mucinous adenocarcinoma with peritoneal metastasis and analyze the prognostic factors.MethodsA retrospective analyses of clinicopathological features of 50 patients with appendiceal mucinous adenocarcinoma with peritoneal metastasis from January, 2013 to December, 2017 in Aerospace Central Hospital, Beijing, China. Survival data calculation and comparison were respectively performed with the Kaplan-Meier method and the log-rank test. The Cox proportional hazards regression method was used for multivariate survival analyses.ResultsCytoreduction for appendiceal mucinous adenocarcinoma was conducted on 50 patients (24 males and 26 females), with a median age of 52.5 years at the time of surgery (range 31–71 years). The median overall survival (OS) time was 24 months, with 2-,3- and 5-year survival rates of 53, 24 and 8%, respectively. At the last follow-up in December 2018, 13 patients were still alive. Multivariate analysis revealed that patients who had low Ki-67 expression (less than 50%) and CCR (completeness of cytoreduction) 0/1/2 score had significantly better OS rate than their respective counterparts.ConclusionsKi-67 expression statue and CCR score could be employed as the prognosis prediction in patients with appendiceal mucinous adenocarcinoma.
Highlights
IntroductionMalignant appendix neoplasms are extremely rare and the incidence of primary appendiceal cancers was less than 1.5% (approximately 0.12 per 1,000,000 person years) according to the appendectomy specimens examination [1,2,3]
Malignant appendix neoplasms are extremely rare and the incidence of primary appendiceal cancers was less than 1.5% according to the appendectomy specimens examination [1,2,3]
According to the 8th edition of the American Joint Committee on Cancer (AJCC) Staging Manual, mucinous adenocarcinomas of the appendix are classified into low-grade and high-grade tumor based on histological grade in the AJCC TNM Staging System [5,6,7]
Summary
Malignant appendix neoplasms are extremely rare and the incidence of primary appendiceal cancers was less than 1.5% (approximately 0.12 per 1,000,000 person years) according to the appendectomy specimens examination [1,2,3]. Due to the low incidence, lacking of available data about the prognostic factors for appendix mucinous adenocarcinomas and non-adenocarcinomas in current clinical practice. We presented our single center data about the clinical and pathological characteristics of appendiceal mucinous adenocarcinoma and analyze the prognostic factors by retrospective review of 50 cases of patients. To investigate the clinical and pathological characteristics of appendiceal mucinous adenocarcinoma with peritoneal metastasis and analyze the prognostic factors
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