Abstract
Introduction: Hepatitis B is a significant public health problem. Infected children Objective: We aimed to assess newborns’ management and outcome from reactive HBs Ag mothers at the El Rapha Polyclinic in Libreville, Gabon. Methodology: Prospective longitudinal study, carried out over four years, including all neonates born from reactive HBsAg mothers admitted in the delivery room. The parameters studied were maternal age, gestation, marital status, pregnancy follow-up, hepatitis B vaccination status, knowledge of hepatitis B, anti-Hbc antibodies’ levels, HBeAg. For the newborn: term, birth weight, management at birth, and hepatitis B serological status at 12 months. Results: We included 45 newborns. Mothers’ mean age was 30.9 ± seven years. In 32.6% of cases, antenatal consultations were ≤4, and 9.3% were vaccinated for hepatitis B. Mothers had chronic hepatitis in 74.4% of cases. All neonates were vaccinated for hepatitis B at birth; 68.9% received hepatitis B immunoglobulin. At 12 months, 77.8% had HBs antibody positive, and 6.7% were HBsAg positive. Conclusion: Hepatitis B prevalence is significant among parturients. It is essential to set up a national strategy for managing the mother-child couple in a context of positive HBsAg.
Highlights
Hepatitis B is a significant public health problem
It is well established that the prevention of mother-to-child transmission (PMTCT) of hepatitis B virus (HBV) plays a key role in reducing the prevalence of the disease
We proposed to study the serological profile of mothers carrying HBsAg and assess the management of their newborns at the El Rapha Polyclinic in Libreville to contribute to advocacy for the introduction into our country’s Expanded Program on Immunization (EPI) vaccine against hepatitis B from birth
Summary
Hepatitis B is a significant public health problem. Infected children
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