Abstract
Malonaldehyde was measured by a colorimetric assay in the cervical mucus specimens of 19 women wearing copper IUDs and 21 women wearing inert IUDs to determine the relationship between copper biochemistry and the potential production of this potential carcinogen. Malonaldehyde was detected in 8 of the 19 specimens from women fitted with copper IUDs but in none of the inert IUD group specimens. The concentrations of the component varied, but were generally in the range of 100 nmol/gm. Based on certain assumptions about the bioreactivity of malonaldehyde, it was estimated that the daily production rate of malonaldehyde associated with copper IUD is from .1-.9 mcmol (7-93 mcg) (this is the cervical rate measurement). Though malonaldehyde is associated with pelvic inflammatory exudates, it is concluded that since the epithelium of the uterus is shed monthly during menstruation, it is unlikely that malonaldehyde associated with the copper IUD is harmful; rather it may have something to do with the copper IUDs' mechanism of action.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
