Malignant transformation in Autosomal Dominant Polycystic Kidney Disease

Abstract

-Background: Autosomal dominant polycystic kidney disease is one of the most common hereditary kidney disorders in adults that may develop malignant transformation. Early diagnosis of such complication is important to get rid of primary malignancy & control of distant metastasis as early as possible. Sudden onset of fulminant hematuria, pain & fever in patient with end stage renal disease & on dialysis may raise the suspicious of such as dangerous complication. This guides us to establish such work to help our patients. -Subject & method: Bedside 2D ultrasound role in characterization of malignant renal mass in adult male patient in collaboration with CT scan of the abdomen & histopathological study of the specimen.-Results: ultrasound & CT scan of the abdomen had a crucial role in characterization of malignant renal mass in patient with autosomal dominant polycystic kidney disease & end stage renal disease. -Conclusion: Sudden onset of gross hematuria in a case of end stage renal disease must raise the concern of malignant transformation of cystic lesion in the kidney.