Abstract

M alignant hyperthermia (MH) is an inherited ,disorder characterized by a hypermetabolic response to succinylcholine and/or potent volatile anesthetic agents (Table 1). It is inherited in humans as an autosomal dominant trait. MH-susceptible patients usually do not have symptoms or signs of problems other than during administration of anesthesia. As such, MH is a prototypical pharmacogenetic disorder, and the only disease of anesthesia. Because an MH crisis may occur wherever and whenever trigger-volatile agents are administered, it is appropriate to be prepared to diagnose and manage an MH crisis wherever general anesthesia is administered, be it a hospital, officg, or ambulatory center. The goal of this article is to provide the most recent information concerning prevention, diagnosis, treatment, and management of MH in the ambulatory setting. The article will address questions associated with managing MH-susceptible patients in a free-standing surgery center as well as a physician's office.

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