Abstract
Magnetic Resonance Spectroscopy (MRS) is nowadays considered as a main MRI investigation modality in the clinical routine jointly with conventional anatomical and functional magnetic resonance imag- ing for studying brain tumours. MRS provides complementary information about cellular metabolism. This allows differentiating the brain tumours from abscess, the diagnosis of the tumour type, characterization of brain tumours, as well as local study of the morphological abnormalities observed in conventional MRI. The MRS could be used in the therapeutic follow-up for evaluating the pathological active area of brain, and allows optimizing the guided biopsy as well as to differentiating recurrent tumour from a necrosis.
Highlights
The magnetic resonance spectroscopy (MRS) is mainly used in biology and in medicine, this investigation modality reports major information about the cellular metabolism
This MR spectroscopy acquisition is lasting 2.30 to 3.40 minutes, and the spectra is immediately available at the end of the acquisition, the acquired data provides limited information about the fraction of the cerebral parenchyma included in the voxel
During the Magnetic Resonance Spectroscopy (MRS) acquisitions with short echo time ranging between 20 and 40 ms) the spectra become complicated and other metabolites are detected including: ˗ The glutamate (Glu) is excitatory neurotransmitter associated with Glutamine (Gln), they increase in the ammonium metabolism abnormalities
Summary
The magnetic resonance spectroscopy (MRS) is mainly used in biology and in medicine, this investigation modality reports major information about the cellular metabolism. The localized MRS identifies the global properties while the MR spectroscopic imaging used recently provides more information about the regional and metabolic heterogeneity within tumors. These MRS features would underline the considered importance of the magnetic resonance spectroscopy as a feasible investigation approach in clinical routine. MRS is used by clinicians for the therapeutic follow-up to estimate the most active area in lesion, to guide and optimize the biopsy, and to differentiate the recurrent tumor a radionecrosis [15,16,17,18] This technique is useful in radiosurgery as a criterion for indicating to increase or decreases the irradiation during tumor radiotherapy [19]
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