Abstract
Degradation experiments are described which establish rigorously structure (II) for neomethymycin (C 25H 43NO 7). This antibiotic belongs, therefore, to the macrolide group and differs from methymycin (I) only in the location of one hydroxyl group, which results in marked changes in chemical behavior. The two antibiotics appear to have the same absolute configuration at the relevant asymmetric centers as inferred by the isolation of a common degradation product and the general similarity of certain rotatory dispersion curves. The position of the hydroxyl group at C-12 in neomethymycin is noteworthy from a biogenetic standpoint.
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