Abstract
From September 1986 to September 1990, 26 patients with aggressive non Hodgkin's lymphoma were treated with the MACOP-B regimen (21 patients as first treatment, 5 relapsed or refractory to an anthracycline derivative containing regimen). 17 patients (65%) achieved a complete response, 4 (15%) had a partial response and 5 (20%) were treatment failures. After complementary radiotherapy 2 patients with PR achieved CR achieving a subsequent CR rate of 73%. CR rate was adversely affected by stage of the disease (IV = 40% vs I + II + III = 80%) and B symptoms (B = 58% vs A = 85%). Relapses occurred in 7 patients (7/19). For complete responders, the Disease-Free-Survival was 55% Over a median follow-up of 20 months, the overall probability of survival was 51%.Toxicity was moderate with no treatment-related toxic deaths but 3 Pneumocystis carinii infections occurring before the introduction of systematic prophylaxis with sulfamethoxazol-trimethoprim. This study confirms the efficiency of the MACOP-B regimen for t...
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