M1152 Influence of Smoking Habits On the Mid-Term Clinical Outcome of New-Onset Crohn's Disease

Abstract

Objective: evaluate the influence of inflammatory bowel disease (IBD) on pregnancy evolution and fetal alterations. Method: the protocols of patients with Crohn's disease (CD) and ulcerative colitis (UC), from 1984 and 2006, in fertile age, followed at the ambulatory of IBD, were reviewed. Patients were interviewed by the research medical doctor, to complete some issues not found in their protocols. Patients with others colitis, incomplete investigation, not in fertile age or without cognitive capacity were excluded from this study. Obstetric history before and after the beginning of symptoms related to IBD, clinical conditions of patients, drugs administered during pregnancy period, preterm delivery, low birth weight, stillbirth, congenital anomalies, spontaneous miscarriage, vaginal and cesarean delivery were investigated. Results: 416 pregnancies in 163 patients before the diagnosis of IBD and 140 pregnancies in 104 patients with IBD were evaluated (UC in 63 pregnancies and CD in 77 pregnancies). IBD was associated with increased preterm delivery (x2=6.7205, p=0.009). There was no statistical difference in low birth weight (x2=0.413 / p=0.5204), congenital anomalies (Fisher test: p=0.6447), stillbirth (Fisher: p=0.2245), spontaneous miscarriage (x2= 4.884, p=0.27), vaginal and cesarean delivery (x2= 1.7959, p=0.1802). There were 63 pregnancies in UC patients, with active disease in 28 and inactive in 35 pregnancies. There were 77 pregnancies in CD patients, with active disease in 57 and inactive in 20 patients. There was no difference between the groups of pregnancies in UC and CD, related to preterm delivery, low birth weight, congenital anomalies, stillbirth and spontaneous miscarriage (p > 0.0649). There was statistical difference in active and inactive disease groups in CD, related to preterm delivery and low birth weight (p < 0.0365). Distribution of alterations in fetus and activity of UC and CD is shown on table 1. Conclusions: preterm delivery rates were higher in pregnancies of CD patients, even with inactive disease during pregnancy. There was no influence of IBD on low birth weight, congenital anomalies, stillbirth and spontaneous miscarriage. Table 1. Distribution of alterations in fetus and activity of UC and CD.