Abstract
A Coulter Counter is used to determine volume changes induced by lysophospholipids in lysosomes, in lysosomal lipid dispersions and in dispersions of pure egg yolk lecithin with added lysolecithin. In each case the increased lysophospholipid content causes an increase in the particle volume along with a decrease in the total number of particles. It is suggested that these volume changes may result from lysosomal or lipid membrane fusion induced by the lyso-compounds.
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