Abstract
The results of studies on the dissociation of the H37 strain of human tubercle bacilli have been reported.1 The variants found were designated “R” indicating resistant to environment and “S” indicating sensitive to environment. This communication records an interesting lytic phenomenon observed during the study of the effect of ageing H37 “R” and “S” variants on gentian violet glycerol egg and plain glycerol egg media of different pH. For clarity it seems advisable to discontinue this usage of the symbols “R” and “S” and to employ them in the usual sense as indicative of a rough or smooth colony structure. To indicate virulence or avirulence the letters (v) or (a) are appended thus “Rv” and “Ra”. Since a smooth variant of H37 which manifests a typical morphology and virulence has not been obtained this terminology has been adopted to cover the virulent and avirulent strains of variants having an “R” morphology.From a dissociated H37 culture1 extreme variants “Ra” and “Rv” were obtained. Each of these vari...
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