Abstract
Lymphoepithelial carcinoma is a rare salivary gland lesion. We retrospectively reviewed CT and MR imaging features of salivary gland lymphoepithelial carcinoma to determine their imaging features and morphologic patterns. The clinical data, CT, and MR imaging findings of 28 patients with histologically proved lymphoepithelial carcinoma of the salivary gland were retrospectively reviewed. Morphologic patterns of the lesions were categorized into 3 types on the basis of margin and shape. There were 17 men and 11 women with a mean age of 39.3 years; 96.4% of patients were positive for Epstein-Barr virus both on histologic staining and Epstein-Barr virus serology. Tumors were parotid in 18 patients, submandibular in 8 patients, sublingual in 1 patient, and palatal in 1 patient. Most tumors (57.1%) manifested as a partially or ill-defined mass with a lobulated or plaque-like shape. Homogeneous enhancement was found in 16 patients, while heterogeneous enhancement was found in 12, including 4 patients with intratumoral necrosis. Invasion into adjacent structures was found in 5 patients; 60.7% of patients exhibited abnormal lymph nodes, with nodal necrosis in 3 patients. The characteristic lobulated or plaque-like shape, with a partially or ill-defined margin, of a salivary gland mass associated with ipsilateral lymphadenopathy may suggest a preoperative diagnosis of lymphoepithelial carcinoma.
Highlights
BACKGROUND AND PURPOSELymphoepithelial carcinoma is a rare salivary gland lesion
The characteristic lobulated or plaque-like shape, with a partially or ill-defined margin, of a salivary gland mass associated with ipsilateral lymphadenopathy may suggest a preoperative diagnosis of lymphoepithelial carcinoma
Lymphoepithelial carcinoma (LEC) is an uncommon malignant neoplasm characterized by undifferentiated malignant epithelial cells with marked infiltration of lymphoid cells in the stroma.[1,2]
Summary
The clinical data, CT, and MR imaging findings of 28 patients with histologically proved lymphoepithelial carcinoma of the salivary gland were retrospectively reviewed. Patients Twenty-eight patients with pathologically confirmed LEC of a major or minor salivary gland were enrolled retrospectively between February 2001 and June 2012. This study was approved by our institutional review board, and patient informed consent was not required in accordance with the requirements of a retrospective study. Clinical data, including age, sex, clinical presentation, laboratory examinations, treatments, and outcomes, were reviewed. Imaging Techniques All patients had cross-sectional imaging before therapy. Of 28 patients, 22 had CT examinations, 5 had MR imaging, and the remaining patient had both CT and MR imaging. Unenhanced and contrast-enhanced CT and MR imaging were performed in all patients
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