Abstract
Summary. T and B lymphocytes can be detected by specific membrane markers. Spontaneous rosette formation with sheep RBC (E rosette) is a T cell marker, whereas receptors for activated complement component (EAC), for the Fc regions of certain immunoglobulin classes (FcR), and for membrane immunoglobulins (mIg) are specific for B cells. Using these lymphocyte membrane markers we evaluated peripheral blood lymphocytes of 18 patients in different stages of acute lymphoblastic leukacmia (ALL).Our results indicate that in acute untreated ALL there is no set immunologic pattern; instead there is a variety of selective deficiencies. Patients in remission have normal populations of T and B cells, whereas those in relapse present a rather obscure picture.The percentage of lymphocytes with membrane markers was compared to the percentage of blast cells and an inverse relation is observed. This indicates that these are abnormal blast cells.The changes from the untreated acute stage through to remission was followed in one subject, and in two others additional study was performed on bone marrow and spinal fluid lymphocytes.
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