Abstract
High benzene exposure is related to acute nonlymphocytic leukemia. Recently, myelodysplastic syndrome has been observed at low benzene exposure levels. We updated a mortality study of workers with benzene exposure examining acute nonlymphocytic leukemia and myelodysplastic syndrome. We calculated standardized mortality ratios with 95% confidence intervals and examined latency and trends for cumulative exposure levels. All leukemias (standardized mortality ratio = 1.21; 95% confidence interval = 0.74 to 1.97) and acute non-lymphocytic leukemia (standardized mortality ratio = 1.04; 95% confidence interval = 0.34 to 2.44) were at expected levels. We observed one death from myelodysplastic syndrome (standardized mortality ratio = 6.48; 95% confidence interval = 0.17 to 38.15). We observed no trend for cumulative exposure levels. Our results for all leukemias are consistent with a small increase in risk observed in the lower-exposed subgroups of the Pliofilm study; however, our results are also consistent with no increased risk especially for acute nonlymphocytic leukemia.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Journal of Occupational & Environmental Medicine
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.